Here's my quick list of favorites from E3 now that I've watched some trailers...
Batman: Arkham Knight - Holy shit this game looks incredible. Such a shame it got pushed back to 2005. The trailer just looked insanely fun.
MGS5 - I've always been a huge Metal Gear Solid fan. The third game was one of my favorites of all-time, and had the best ending ever. I'm looking forward to going back to that sort of tone and playing as Big Boss again.
Uncharted 4 - Visually this game will obviously be amazing. I just hope it's not like Uncharted 3, and by that I mean a carbon copy of the second game. I liked Uncharted 3, but overall it was just too much of the same...the same basic storyline, the same set-pieces, etc. It just felt a little stale at times.
No Man's Sky - Hot damn this game looks fantastic. The idea of seamlessly jumping into a ship on a planet and flying into outer space to do combat is just awesome. I really hope this has Oculus Rift support.
Evolve - Always had a ton of fun playing L4D with friends on the PC. This looks like more of that, which I am okay with.
Edit: Oh yeah, and The Witcher 3! Game looks phenomenal.