@col63onel
Obviously, your mileage may vary, but Jessica Jones is my favorite of the Netflix/Marvel fare, with Daredevil probably next. Luke Cage was also good, but as much as I have historically loved the Iron Fist character, I thought this representation was pretty poor. The Defenders probably should not be watched without viewing at least some of the other series, but all the individual series are certainly watchable and understandable independent of the others, even as a group they enhance your understanding of this "universe". Enjoy!