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Pioneer10

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I’m not going to believe the medical professionals. Just going to listen to the guys I went to high school with.
I went to high school:cool:
It was a long time ago and I try to forget that time particularly my haircut but I think it happened
 

Pioneer10

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One problem: is don't trust in vitro studies. The number of treatments that work in a dish or a mouse is a thousandfold more then what actually works in human beings.

Frankly, the "clinical trials" with hydroxychloroquine are just glorified case reports at this points. The French study for example had no error bars as they didn't collect the same tests at their starting point versus what they reported in as their end points
 

Zeus69

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There are many articles about In vitro and a few on in Vivo.....I will include some things here:

From Medicine Du Translated from Chinese On February 20, the official website of Wuhan University People's Hospital reprinted a report in the Health Daily entitled "The short-term effects of hydroxychloroquine in the treatment of new coronary pneumonia". In the report, the researchers found early in the hospital dermatology treatment of 80 patients with systemic lupus erythematosus found that no one was infected with the new coronavirus pneumonia, because of the suspicion that this phenomenon is related to the long-term use of hydroxychloroquine patients, the team proposed to conduct hydroxychloroquine treatment of patients with neo-coronavirus pneumonia clinical trials.

According to the report, as of February 17, the hospital "hydroxychloroquine and basic treatment group" into the group of 20 patients with new coronary pneumonia, after the treatment of hydroxychloroquine treatment, patients in 1 to 2 days of clinical symptoms significantly improved. After 5 days of use, chest CT was reviewed, 19 patients had significant absorption improvement, and only 1 patient (previously had renal insufficiency) had progressin chest CT, but the patient had a significant improvement in clinical symptoms on the second day of use of hydroxychloroquine. In addition, none of the general patients in the group developed critical condition, and one of them was discharged on 13 February.



There is also this:

Indian Council of Medical research recommending Plaquenil prophylaxis:
 

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Zeus69

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The coronavirus isn't mutating quickly, suggesting a vaccine would offer lasting protection

Source: WaPo

The coronavirus is not mutating significantly as it circulates through the human population, according to scientists who are closely studying the novel pathogen’s genetic code. That relative stability suggests the virus is less likely to become more or less dangerous as it spreads, and represents encouraging news for researchers hoping to create a long-lasting vaccine.

All viruses evolve over time, accumulating mutations as they replicate imperfectly inside a host’s cells in tremendous numbers and then spread through a population, with some of those mutations persisting through natural selection. The new coronavirus has proofreading machinery, however, and that reduces the “error rate” and the pace of mutation. The new coronavirus looks pretty much the same everywhere it has appeared, the scientists say, and there is no evidence that some strains are deadlier than others.

SARS-CoV-2, the virus that causes the disease covid-19, is similar to coronaviruses that circulate naturally in bats. It jumped into the human species last year in Wuhan, China, likely through an intermediate species — possibly a pangolin, an endangered anteater whose scales are trafficked for traditional medicine.
AD

Scientists now are studying more than 1,000 different samples of the virus, Peter Thielen, a molecular geneticist at the Johns Hopkins University Applied Physics Laboratory who has been studying the virus, told The Washington Post.

 

Hurl Bruce

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Can you recommend supplies that we should have in our house in case we get infected but aren't to the level that we need to be in a hospital? Tylenol, Tamiflu, types of food/drink, etc... @Zeus69 @Pioneer10
 

Man Called X

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Can you recommend supplies that we should have in our house in case we get infected but aren't to the level that we need to be in a hospital? Tylenol, Tamiflu, types of food/drink, etc... @Zeus69 @Pioneer10
I'm not a medical professional, but Tylenol is the one suggested for fever, but good luck finding any in stores.

Personally, I always stock up on Sambucol during the flu season anyway. Whether it will have any effect on Covid-19, I don't know, but it's worth a shot. While I don't know of any clinical trials to prove it's effectiveness, but I know it's shown effectiveness against flu strains in vitro studies.
 
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Zeus69

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Can you recommend supplies that we should have in our house in case we get infected but aren't to the level that we need to be in a hospital? Tylenol, Tamiflu, types of food/drink, etc... @Zeus69 @Pioneer10
Here are some things I have in my medicine cabinet:

XS Tylenol
Mucinex D and DM
Zinc 50
Vit C 500
Vit D3 1000
Electrolytes (gatorade etc.)
Hydrogen peroxide (for gargle, 2 parts water, 1 part peroxide)
All kinds of throat lozenges

I take a Men's Daily multivitamin at this time. Have upped my intake of fruits and vegetables. Daily exercise and cardio. Nothing additional.
 

Zeus69

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Study of 206 monoclonal antibodies against #SARSCoV2 isolated from 8 #COVID19 patients. Some antibody clones are highly effective at neutralizing live SARS-CoV-2 virus in cells, suggesting that we now know human antibody sequences that would be effective COVID-19 drugs.

In addition, the authors observed interesting cross-reactivity of antibodies against SARS-CoV & MERS-CoV trimeric spike protein, but not against SARS-CoV & MERS-CoV spike receptor-binding domain, suggesting unusual antibody response viral specificity.

Yes, very good news. There are now multiple reports of monoclonal (we know exactly which protein sequence needs to be manufactured) human (should be quite safe as drugs) antibodies that block the #SARSCoV2 virus that causes #COVID19. Same strategy as was used to treat Ebola.
 

Pioneer10

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Can you recommend supplies that we should have in our house in case we get infected but aren't to the level that we need to be in a hospital? Tylenol, Tamiflu, types of food/drink, etc... @Zeus69 @Pioneer10
Thoughts and prayers.

Only half-joking: it's all symptomatic treatment (i.e. tylenol for fever, guanfacine for cough) at this point. As noted I'm very wary of the chloroquine stories right now: worth investigating but the data supporting is highly misleading.

The ACE receptor binding of the Covid19 virus into the lung makes you wonder about very popular blood pressure drugs such as ACE inhibitors or ARBs. As a precaution, I'm holding off on taking my lisinopril for now till we get more information on whether there is any concerns (or benefits) for now
 

Hydroponic3385

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This 5 minute video may be the favorite one I've found so far on coping with mental health distress related to the covid pandemic. The guy who made the video (Dr. Russ Harris) is the guru when it comes to Acceptance and Commitment Therapy, which is very evidence-based:
 

Zeus69

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Antibody test to determine whether someone has been exposed to COVID-19 and mounted an immune response (essentially being "vaccinated" - duration of immunity still unknown)

 

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