The only thing holding Kyrie out is our record.
Seriously though, he is the best guard in the East with the possible exception of D-Wade when he is on, and maybe Rondo, because they play different games.
If he isn't the first guard on the bench, there are serious issues with how this is done. Deron Williams is awful this year, Jennings' numbers are too inferior, regardless if the Bucks are better, Jrue Holiday makes a case... who else is there? Kemba? Bobcats suck too.
Rondo, Wade, Irving, and Holiday would be my guard picks.