Actually, I think the center position is making something of a comeback. Embiid, Jokic, KAT, Gobert, Vuc, Horford, Nurkic....In fact, teams with good centers constituted 7 of the 8 teams that made the conference semifinals last year.
The truth is that what works in college isn't always going to work in the pros because pro athletes are bigger, faster, and can cover more ground defensively. They shrink the court. The wishbone offense in football, which was a mainstay of the college game even through much of the 80's, has largely died out because modern NCAA linebackers tend to be too fast. And in the NBA, there are too many big men whose combination of foot speed and length can counter the quickness of guards. Then, the team with more size can absolutely abuse the shrimpos on the offensive end because the team with 3-4 guards will get clobbered due to lack of size.